Betty Jo (Roberts) Cain, 87, of Inez, Kentucky passed away Tuesday, March 22, 2022 at Highlands ARH in Prestonsburg, KY. Betty Jo was born October 28, 1934 in Williamson, WV to the late Lewis Jackson "LJ" and Easter Jane (Young) Roberts. In addition to her parents, she is preceded in death by her husband, Willard Cain, children, Gary Michael Cain, Randy Dwayne Cain, Joey Cain and Deborah Renee Cain, and grandchildren, Raquel Renee Cain and Phillip Brian Cain. She is survived by her son, Larry Dean (Becky) Cain of Inez, KY, grandchildren, Gary Michael Cain II of Frankfort, KY, Larry Daniel (Stephanie) Jude of Prestonsburg, KY, Williard Robert (Tiffani) Cain of The Colony, TX, Jacob Harrison Cain of Inez, KY, Caitlin Elizabeth (Ryan) Birchfield of Murfreesboro, TN, Kayla Lynae (Marcus) Simpkins of Lovely, KY, and Cody Collier (Samantha) Freeman of Lexington, KY, great granddaughters, McKenna Taylor Cain of Richmond, KY, Emery Glynn Cain of The Colony, TX, Aleah Ray Jude of Prestonsburg, KY and Great Grandson, Alexander Christian Jude of Prestonsburg, KY. Funeral services will be held on Saturday, March 26, 2022 at 1 PM in the chapel of Crum Funeral Home with Phillip Kirk officiating. Burial will follow at the family cemetery on Coldwater. Friends may visit at the funeral home from 5 PM to 9 PM on Friday and on Saturday from 10 AM until the time of services. Arrangements are under the direction of Crum Funeral Home of Inez, KY.